IL23R&IL12RB1 HEK293
CBP74609
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| I. Background | |
| IL23R与IL12RB1共同组成白细胞介素-23（IL-23）的异二聚体受体复合物。IL-23是一种关键的促炎性细胞因子，主要由活化的树突状细胞和巨噬细胞分泌，在Th17细胞的分化、维持和功能执行中发挥核心作用。该信号轴过度激活与银屑病、炎症性肠病、类风湿关节炎等多种自身免疫性疾病的发病密切相关。结合后，该复合物主要激活JAK-STAT信号通路，驱动炎症反应。 | |
| II. Description | |
| IL23R&IL12RB1 HEK293细胞，在 HEK293细胞的基础上，稳定表达 IL23R&IL12RB1 。 | |
| III. Introduction | |
| Expressed gene: | IL23R&IL12RB1 |
| Host Cell: | HEK293 |
| Stability: | 32 passages (in-house test, that not means the cell line will be instable beyond the passages we tested.) |
| Freeze Medium: | 90% FBS+10% DMSO |
| Culture Medium: | DMEM+10%FBS+2 μg/ml Puromycin +5 μg/ml Blasticidin |
| Mycoplasma Testing: | Negative |
| Storage: | Liquid nitrogen |
| Application(s): | Binding Assay,FACS |
| IV. Representative Data | |
 Figure 1. Recombinant IL23R&IL12RB1 HEK293 constitutively expressing IL23R&IL12RB1 . |
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